Non-coding amino acids Significantly smaller than their parent molecule, Azurin Simple structures Easy to manufacture Bind directly to both viral and host proteins to inhibit infection
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ΓÇó Reduce cytotoxicity of therapeutic agents by targeting them to specific cells ΓÇó Improved specificity of chemotherapy to cancer cells
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Researchers from UC San Diego have identified which two phosphotyrosines in GIV interact directly with two domains of PI3K that stabilize receptor association of PI3K and trigger production of PIP3 (phosphotidylinositol-3,4,5-triphosphate) at the plasma membrane during cell migration. Previously.....
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The current treatment of heart failure is often heart transplantation. UCSD researchers have developed an alternative treatment for heart failure by regulating cytostolic calcium fluxes, in order to improve contractile function. Calcium regulation is achieved by enhancing the expression of a calcium.....
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Utilizing both these immunosuppressive mechanisms, UCLA scientists have determined that perillyl alcohol, a widely-known anti-carcinogen, can be used to reduce graft rejection. By inhibiting activation of the p2l ras oncogene, perillyl alcohol blocks activation of the pathway necessary for lymphocyt.....
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