Significantly reduce the time it takes to diagnose a flavivirus infectionReplaces current use of IgM MAC-ELISA’s and IgG ELISA plus plaque reduction neutralization (PRN) test with a single, equally sensitive, faster test.Volume of CSF fluid needed is less (10-20 μl)Less technician timeLess costlyCan.....
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Identification of non-ATP-competitive ligands. Ability to selectively target only the disease associated isoforms of PKA. Screening of compounds that modulate PKA function through stabilizing active or inactive conformational states. Identification of both.....
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Non-invasive, lower cost DNA methods for diagnosis; Carrier detection at time of birth; Small required amount of DNA for testing; and, More informed breeding decisions.
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Offers a powerful therapeutic platform based on DNA—a molecule approved for in vivo human use. Avoids the conjugation chemistries typically associated with conferring target specificity, biocompatibility, and drug incorporation. Provides a multifunctional platform for integrating many cancer.....
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This present invention is particularly useful in obtaining quantitative optical properties and chromophore concentrations of tissue components in vivo at superficial depths and "short" source-detector separations. The probe is amenable to use in free space or in tissues that can be reached by endos.....
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