UC San Diego researchers have developed biochemical logic methods and systems for rapid, high-fidelity diagnostics. The invention employs multiple markers as inputs to biochemical logic gates (e.g., “AND” and “XOR”) to trigger a cascade of enzymatic reactions and thus compute a final, digital answer.....
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Scientists at UC San Diego have discovered sensitive and accurate assays for gene detection, genome-wide gene expression profiling, and alternative splice monitoring with minimal or no target-specific amplification. The technology relates to a novel approach of detecting and quantifying DNA and RNA .....
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ELISA Assay There is currently no quantitative, high-throughput assay for FMRP levels from peripheral white blood cells (FMRP is an intracellular protein that is not detectable in cell-free serum). The FMRP ELISA test is both quantitative and high-throughput, since samples can be run in a 96-well fo.....
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Simplifies extraction and purification methods Mechanical or chemical extraction is no longer required resulting in lower levels of impurities No mis-folding due to over expression in cytoplasm
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The invention identifies over-riding principles and concepts, which are readily translated to models constructed upon different assumptions. Also, while validated for one metabolic pathway, this has direct applicability to other biological processes, including but not limited to signaling networks, .....
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