UC San Diego researchers have developed biochemical logic methods and systems for rapid, high-fidelity diagnostics. The invention employs multiple markers as inputs to biochemical logic gates (e.g., “AND” and “XOR”) to trigger a cascade of enzymatic reactions and thus compute a final, digital answer.....
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Our microfluidic Ladder Chamber is capable of generating stable concentration gradients across 2D surfaces and 3D matrices. Neutrophil chemotaxis was successfully demonstrated in the Ladder Chamber. Compared to other assays, this chamber offers simplicity and improved stability of the gradients. In .....
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The non-coding U1 snRNA potentially can be used to induce tissue necrosis in certain types of cancers and may have therapeutic applications in infectious diseases. Conversely, anti RNAs could be synthesized to block the inflammatory effects of U1 snRNA, or TLR3 antagonists could be used to attenuate.....
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Gene therapy, gene transfection, drug delivery, plasmid DNA and shRNA for pharmaceutical and therapeutic applications
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Investigators have tested the combination of adjuvants (alum and MPL) in a mice model of Influenza A infection. Mice primed with nucleoprotein of influenza A (NP) and both adjuvant lost less weight and quickly regained their original weight in contrast to mice primed with NP/protein and either adjuv.....
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