Membrane proteins (MP) mediate many of the cell’s fundamental processes and MPs are embedded in the cell’s membrane lipid bilayer. Currently, MPs are targets for about 60% of therapeutic drugs in use. However, MPs are very difficult to manipulate and study because they require both an aqueous enviro.....
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It has been discovered that As.sub.2O.sub.3 suppresses tyrosine kinase receptors, in particular EGFR and IL-6R, by targeting RTKs to lysosomes and/or proteasome for degradation. This is the basis for the discovery that cancers dependent on RTKs for signaling, proliferation, survival, metastasis and .....
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A novel class of saturated or conjugated dendrimers containing at least one strong .sigma.-donating group coordinated to cyclometalated tridentate gold(III) compounds having the chemical structure depicted by generic formula: ##STR00001## wherein: (a) [Au] is a cyclometalated tridentate gold(III) gr.....
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A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression of one or more protein biomarks in the group consisting albumin, T-kininogen I, [alpha]-2-HS glycoprotein.....
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A tunable laser has a fibre Bragg grating anchored at each to relatively movable fixtures and an actuator coupled to the fixtures for creating relative movement that longitudinally stretches or compresses the fibre Bragg grating. Measuring means are arranged to directly monitor a longitudinal separa.....
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