Carbonic anhydrase inhibitors and their use as chemosensitizing agents in the treatment of cancers
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Novel mAbs that bind a unique epitope on a cancer-associated form of the ADAM10 metalloprotease. Inhibiting ADAM10 blocks activation of receptors linked to the ‘stem cell niche’ and depletes cancer stem cells resistant to chemotherapeutic treatments. The lead mAb is potentially useful as ‘cancer spe.....
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