PAC-1 and related compounds are small molecules capable of specifically killing cancer cells by inducing apoptosis. It does so by targeting an inactive apoptotic precursor, procaspase-3, that is up regulated in many cancer types. In vitro and in vivo studies have shown PAC-1 to be efficacious in red.....
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As many as 60 million Americans have hypertension, the medical term for high blood pressure. Uncontrolled hypertension is a major factor in many cases of death and disability resulting from heart attack, stroke, and kidney failure. Current guidelines for the treatment of hypertension recommend an an.....
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Project ID: D2015-01Device NoveltyA feedback controlled pressure output system designed to precisely deliver air stimuli to upper aero digestive tract mucosa for the evaluation of dysphagia, laryngopharyngeal reflux, aspiration potential, and obstructive sleep apnea therapy compliance.Background Dys.....
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Lead Inventors: Nicole Suciu-Foca, Ph.D.Problem or Unmet Need:Transplantation medicine is a relatively new and growing field allowing thousands of lives per year to be saved which otherwise would have succumbed to end-organ failure. However, since currently the only source of organs is from allogene.....
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Lead Inventors: Sherie L. Morrison PhDAn antibody having a binding site region and a domain-modified constant region. The domain-modified constant region is a substitution, duplication, or deletion of substantially all of the amino acids of constant region domains. The functional properties of the d.....
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