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Lawsonia Antigens

Detailed Technology Description

Livestock Vaccination from Lawsonia Intracellularis AntigensA gene region from Lawsonia intracellularis has been identified that contains highly expressed potential antigens for diagnostic or vaccine development for livestock. Lawsonia intracellularis is a fastidious intracellular bacterium that causes an intestinal hyperplasic disease characterized by thickening of the mucosa of the intestine due to enterocyte proliferation. Vaccines produced from these markers could become the best-in-class option for livestock vaccination. Farmers would be quick to adopt these vaccines because their cost is far outweighed by that of infected livestock.MN-IP Try and BuyTryTrial period: 12 to 18 months. $5000/6 months.Fee waived if MN-based company or if sponsoring $50,000+ in research.BuyExclusive license for a $15,000 conversion paymentAdditional patent expenses due3% royalty after $1 million of product salesDiscount for MN companies** View the Term Sheet **** Contact Rebecca Gerber for specific details. **Need for Lawsonia Vaccine DevelopmentLost production due to infection is a major cost for the livestock industry every year. Lawsonia intracellularis is a bacterium that causes infections in many mammalian species, but especially pigs. Lawsonia infections stunt growth and cause mortality, downgrading the value of the herd. There are Lawsonia vaccines available on the market, but they have not been 100% effective, and thus the problem persists. Lawsonia infections are at an endemic level, but an improved vaccine has the potential to significantly lower the prevalence of infection.BENEFITS OF NEW TARGETS ON THE LAWSONIA INTRACELULARIS GENOMEVaccine developed against Lawsonia intracellularis would reduce mortality of mammals and risk of stunted growth due to infectionNovel targets for L. Intracellularis vaccineMarket pull for development of better vaccines - Current vaccines are not 100% effectiveDiagnostics or vaccines could limit lost production due to infectionHigh infection rate of pigs in the U.S.Endemic status in pigs and a rising concern in horsesMajority of U.S. herds are infected

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Country/Region

USA