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C18R7RGDS self-assembled amphiphililc peptide nanoparticles (APNPs) as a novel hydrophobic drug carrier in aqueous solution

Technology Benefits

The drug carrier:ΓÇóIs a potential chemotherapeutic candidate, highly selective for osteosarcoma cellsΓÇóUses a simplified process for encapsulating hydrophobic drugsΓÇóComprises nano-scale biomaterials for various nano-medicine applicationsΓÇóEnables an efficient cell penetration, especially for cancerous cellsΓÇóAllows encapsulation of external molecules and delivery inside cells/tissuesΓÇóHas an effective/enhanced drug loading capability as compared to conventional carriersΓÇóAllows dissolution of hydrophobic drugs to form a homogeneous solution in waterΓÇóAllows for an improved drug delivery, especially for indications such as cancer, diabetes, osteoporosis, and tissue regeneration

Detailed Technology Description

None

*Abstract

In prior-art, the use of drug carriers for improving the drug delivery is well known. However, only few carriers are capable of delivering hydrophobic drugs effectively. Moreover, the drug encapsulation procedures used by such carriers, especially for hydrophobic drugs, are highly cumbersome. In addition, some of the commonly used drug delivery carriers such as liposomes are highly toxic in nature, capable of inducing kidney damage (s). This invention relates to a novel and efficient hydrophobic drug carrier comprising self-assembled amphiphilic peptide nanoparticles, capable of overcoming prior-art limitations and/or addressing unmet needs.

*Principal Investigator

Name: Run Chang

Department:

Name: Linlin Sun

Department:

Name: Thomas Webster

Department:

Country/Region

USA