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Inhibitors of Polyisoprenylated Methylated Protein Methyl Esterase

詳細技術說明

The invention is in the field of inhibitors for the enzyme polyisoprenylated methylated protein methyl esterase (PMPMEase). The invention is also in the field of methods for medical treatment using inhibitors of the enzyme PMPMEase. The invention is further in the field of using PMPEase inhibitors for diagnostic or clinical applications.

*Abstract

Inhibitors of the enzyme prenylated methylated protein methyl esterase (PMPMEase), the last step in the prenylation process for many eukaryotic proteins, having the general structure R₁-X-A-B(R₂)-Y or R₁-X-A(R₂)-B-Y, where R₁ is preferably a polyisoprenyl group, X is a linking group, Y is a group that promotes affinity interactions to the active site of PMPMEase and imparts hydrolysis resistance to the inhibitor, A and B are bridge atoms, and R₂ is a characteristic providing substituent.

國家/地區

美國