Protein Acyl Transferase Inhibitor
- 技術優勢
- Promising new cancer treatment, High-throughput screening technique
- 詳細技術說明
- USF scientistsΓÇÖ have developed a method for screening a combinatorial compound library in a way that has resulted in the identification of a compound that inhibits the PATs that modify the Ras oncogene protein. Mutation involving Ras proteins have been estimated to contribute to the pathology of over 30% of all human cancers. Palmitoylation is required for the function of three of the four forms of Ras. Thus an inhibitor of a Ras PAT is a promising new tool designed to inhibit Ras function in cancer cells.
- *Abstract
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Researchers at the University of South Florida have developed a method for screening a combinatorial compound library, as well as the identification of a novel protein acyl transferase inhibitor for the treatment of various cancers.
- 國家/地區
- 美國
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