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OCT-1: A Novel Antisense Strategy to Reduce Tumor

*Abstract: Oncoproteins,the products encoded by oncogenes, can induce cancer in animalsand transform normal cells in culture to become cancerous cells. Multiple factors are involved in the production of oncoproteins. One such factor, Oct-1 is a ubiquitously expressed transcription factor that binds to an eight nucleotide sequence (ATTTGCAT) in the promoters and enhancers of a number of genes. It is a member of a family of transcription factors containing a POU domain and a bipartite DNA-binding domain. Oct-1 has been shown to regulate the transcription of many genes. The present technology captures a new and significant finding of anantisense strategy that was used to reduce Oct-1 and consequently to lower tumorphenotype.

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