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Small Molecules to Promote Bone Growth

標題

Diphenylacrylic Acid Derivatives That Promote Bone and Cartilage Growth

詳細技術說明

ApplicationCarrier-linked small molecules that disrupt noggin function and promote bone and cartilage growth.Key BenefitsReduces the patient's dosage of recombinant bone morphogenetic proteins (rhBMP)Improves the effectiveness of less potent bone inducers.Small molecules are cheaper to manufacture, and store compared to protein biologic rhBMP.Reduced side effects compared to recombinant human BMP products.Market SummaryBone is known as the second most implanted material in the body. It is estimated that bone grafts are used in over 1 million procedures annually in the US. Bone morphogenetic proteins (BMP's) are potent growth factors that induce bone and cartilage formation. Noggin is an extracellular protein that regulates the activity of BMP's by binding them and preventing them from binding to their cell surface receptors, which is required to initiate the BMP signaling pathway. In addition, noggin can limit the effectiveness of exogenously applied BMPs. There is a need for better and more efficient drugs/approaches for bone healing that can be localized and have reduced side effects.Technical SummaryEmory researchers have developed small molecule blockers that block BMP-2 from binding to noggin. This small molecular blocker can create a local "BMP-privileged healing zone." Inhibiting noggin may enhance less potent bone inducers to encourage cells to become active osteoblasts without the use of exogenous BMPs. Also, the patient's dose of BMP required may be reduced, decreasing local side effects. This small molecule may be used in orthopedic applications such as spinal fusions and oral surgery.Developmental StageIn vivo data available that indicate improved bone forming characteristics.

*Abstract

None

*Principal Investigation

Name: Scott Boden, Professor of Orthopaedic Surgery

Department: SOM: Orthopaedics: Admin

Name: Sreedhara Sangadala, Assistant Professor

Department: SOM: Orthopaedics: Admin

申請日期

Apr 5, 2017

國家/地區

美國