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Novel Adenylyl Cyclase 1 Inhibitors for Chronic Pain and Opioid Dependence

總結

Researchers at Purdue University have developed compounds that may provide an effective method of treatment for chronic and inflammatory pain by inhibiting selective adenylyl cyclases, especially adenylyl cyclase 1. These compounds may also prevent and/or reduce opioid dependence.

技術優勢

Chronic and inflammatory pain reliefNon-opioidNon-addictivePossibly treat opioid dependence

技術應用

Pain treatmentOpioid dependence treatment option

詳細技術說明

Val J. WattsVal J. Watts LabPurdue Medicinal Chemistry and Molecular Pharmacology

*Abstract

None

*Background

According to a 2012 study by the American Pain Society, the annual cost of chronic pain in the United States is as high as $635 million, impacting more than 100 million people. According to the Centers for Disease Control and Prevention (CDC), 91 people die in the U.S. every day from an opioid overdose. Chronic and inflammatory pain are treated with antidepressants, anticonvulsants, and/or opioids. The use of opioids often leads to opioid dependence, which is treated with opioid substitutes such as methadone, buprenorphine, or opioid antagonists. There is a need for a treatment option for chronic and inflammatory pain that provides effective pain relief as well as eliminates opioid addiction and dependence.

*IP Issue Date

None

*IP Type

Provisional

*Stage of Development

Bench testing performed

*Web Links

Purdue Office of Technology CommercializationPurdue Innovation and EntrepreneurshipVal J. WattsVal J. Watts LabPurdue Medicinal Chemistry and Molecular Pharmacology

國家

United States

申請號碼

None

國家/地區

美國