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Improving Outcome after Respiratory Infection: Novel Microbiome Therapeutic

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Description: Researchat Kansas State University has discovered a novel approach for improvingresponse to respiratory pathogens through modulating the gut microbiome.  The microbiome is defined as the collectionof microorganisms in the gastrointestinal tact (GI) that are critical for the developmentof immunity and digestion of nutrients.  It is well known that probiotics can help alleviateGI issues in humans and animals. However, our research has shown that modulating the microbiome of animals prior to challenge withrespiratory pathogens reduces morbidity and mortality associated withinfection.  This pioneering research at K-State is the first tomake the connection between a healthy & diverse gut microbiome incommercial pigs and enhanced immunity against the most significant and costly respiratory diseases of swine.Porcine reproductive and respiratory syndrome virus(PRRSV) and porcine circovirus type 2 (PCV2) are two of the most importantpathogens affecting the swine industry, decreasing production and animalwelfare due to respiratory disease and reduced growth performance.  In a co-infection model using PRRSV and PCV2,we showed that high-health conventional nursery pigs administered a microbiome therapeuticat weaning had significantly higher survival (Fig), reduced clinical disease, anddecreased virus replication when compared to controls.Advantages: ·        Enhancing immunity against respiratory pathogens·        Natural alternative to antibioticsApplications:  ·        Potential new product category·        Adjuvant to standard vaccination practices·        Prevention of disease caused by respiratorypathogens·        Improved response after exposure to respiratorypathogensPatent Status:  Provisional Patent application filed in May 2017.Interested parties should contact:Kansas State University Institute for Commercialization (KSU-IC)2005 Research Park Circle Manhattan, KS 66502Tel: 785-532-3900 Fax: 785-532-3909E-Mail: ic@k-state.edu

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美國