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Specific inhibition of caspase-2 activation for the treatment of neurodegenerative diseases

總結

This technology is a membrane-permeable hexapeptide that specifically inhibits caspase-2 signaling in the central nervous system to treat neurodegenerative diseases.

技術優勢

Specifically inhibits caspase-2 signalingDoes not interfere with other cellular pathways in the brainPenetrates cell membranes for enhanced drug delivery

技術應用

Treatment of neurodegenerative diseases, including Alzheimer’s disease, mild cognitive impairment Parkinson’s disease, Huntington’s chorea, amyotrophic lateral sclerosis, and Creutzfeld-Jacob diseaseResearch tool for understanding the role of caspase-2 and RAIDD in cellular signaling

詳細技術說明

None

*Abstract

None

*Inquiry

Jerry KokoshkaColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU12019

*Principal Investigation

*Publications

Jean YY, Ribe EM, Pero ME, Moskalenko M, Iqbal Z, Marks LJ, Greene LA, Troy CM. “Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death” Biochem J. 2013 Oct 1; 455(1): 15-25. Pozueta J, Lefort R, Ribe EM, Troy CM, Arancio O, Shelanski M. “Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice” Nat Commun. 2013 Jun 10; 4: 1939.Ribe EM, Jean YY, Goldstein RL, Manzl C, Stefanis L, Villunger A, Troy CM. “Neuronal caspase 2 activity and function requires RAIDD, but not PIDD” Biochem J. 2012 Jun 15; 444(3): 591-599.Tech Ventures Reference:IR CU12019Licensing Contact: Jerry Kokoshka

國家/地區

美國