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Utility of DNA Damage Markers in Prostate Cancer Diagnosis

詳細技術說明

Title: Utility of DNA Damage Markers in Prostate Cancer Diagnosis Invention: The invention uses data from the expression of RAD51 (a marker of DNA repair and a cancer biomarker) and other selected biomarkers in prostate tissue samples to improve prostate cancer diagnoses. Increased expression of RAD51 has been associated with more aggressive forms of prostate cancer (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856636/).  Thus an identification of an overt expression of RAD51 or lackthereof can help doctors determine a proper course of action pertaining to a patients treatment.Background: Every year about 233,000 new cases of prostate cancer are diagnosed, of these cases over 29,000 men die each year of this disease. Through the decades the 5-year survival rate of prostate cancer has climbed significantly from 66% in 1975 to nearly 99% today. Be that as it may, prostate cancers is still one of the leading killers in men over the age of 40. It is recommended that men over the age of 50 discuss proper screening for prostate cancer with their doctors. Current screening for prostate cancer includes testing the amount of prostate-specific antigen (PSA) in a man's blood. In other cases a biopsy may be necessary.Advantages:Current diagnostic methods for prostate cancer detection miss a considerable amount of cases. They also utilize biomarkers that are not specific to prostate cancer, which results in unpleasant and unnecessary treatment for some patients.  Deficiencies in current methods result in misdiagnoses, sometimes resulting in preventable cases of disease progression, metastasis and death. Improved diagnostic information from this method will enable physicians and patients to make more informed decisions regarding treatment which will lead to better patient outcomes and satisfaction.  Licensing Manager:Rakhi GibbonsRakhiG@TLA.arizona.edu(520) 626-6695

*Abstract

None

*Principal Investigation

Name: Amit Algotar, Assistant Ressearch Scientist

Department: Cancer Center Division

Name: Anne Cress, Professor

Department: Cellular & Molecular Medicine

Name: Steven Stratton, Associate Professor

Department: Cancer Center Division

Name: Naran Lodhia, Student Group B

Department: Molecular and Cellular Biology

國家/地區

美國