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Metabotropic Glutamate Receptor 8 (mGluR8) knockout mice

*Abstract

During the ten years he was at the Weill Cornell Medical College, Robert Duvoisin (now at Oregon Health and Science University) cloned the mouse mGluR8 gene and generated a KO mouse.

 

The mouse has no obvious phenotype, although there is a slight increase in anxiety-related behavior, and an absence of L-AP4 inhibition of synaptic transmission in the lateral perforant path of the hippocampus.

*Licensing

Vibhu Sachdev(212) 746-6187sachdev@cornell.edu

其他

• Cai Z, et al (2001) Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors. J Neurochem. 78(4):756-66. (shows absence of L-AP4 inhibition)
• Duvoisin RM, et al (1995) A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J Neurosci. 15(4):3075-83.
• Gerlai R, et al (2002) Performance deficits of mGluR8 knockout mice in learning tasks: the effects of null mutation and the background genotype. Neuropharmacology 43(2):235-49.
• Linden AM, et al (2002 Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor. Neuropharmacology. 43(2):251-9.
• Sansig G, et al (2001) Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. J Neurosci. 21(22):8734-45. (mGluR8 KO is compared to other KOs)
• Zhai J, et al (2002) Modulation of lateral perforant path excitatory responses by metabotropic glutamate 8 (mGlu8) receptors. Neuropharmacology 43(2):223-30.

國家/地區

美國