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An Improved Biocompatible Micro-patterned Implant Surface to Promote Cell Adhesion

詳細技術說明

The invention relates to a biomedical implant systemfor use in a fluid shear stress environment. It containscellular niches (porous scaffolds) that allow for cellular growth on the device surfaces.

*Abstract

Cornell researchers have developed surface modification geometry for implantable materials and devices, which protects both sensory elements as well as adhering cells from shear stresses while allowing them to interact directly with the surrounding media.

 

This innovation offers improved cell anchoring to the device by way of cellular niches in the surface geometry, promoting cell survival and proliferation within this interface. As a result, patient acceptance of the device is improved.

 

Potential Applications
An improved micro-patterned surface for implanted medical devices (e.g. cardiovascular implants).

 

Advantages

• Overcomes limitations of other device surfaces by creatingmechanically protected niche environments where adherent cells can restore andmaintain homeostasis.
• Improvement over porous scaffold based devices, which havelessened integrity due to the nature of the surface.
• Improved acceptance of the device by patients with lowerincidence of rejection and faster healing time.
• Patient would require less anti-coagulant drug therapies.
• Improved quality of life for the patient.

  

*Licensing

Jeff Fearnjcf55@cornell.edu607-254-4502

其他

• Patent issued in the U.S. under the number 9,629,713.
• Christopher M.Frendl, et al. Endothelial retention andphenotype on carbonized cardiovascular implant surfaces. Biomaterials. 35;27: 7714-7723.
• “Patented biomedical implantcould improve heart patient outcome” by Tom Fleischman Cornell Chronicle, Aug.9, 2017. 

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