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Corneal Hydration Sensing with Thz Illumination

技術優勢: Low-power Non-invasive No direct contact with the corneal tissue Robust to user error Measures hydration directly

技術應用: Detecting inflammation, immune response, edema or disease in the cornea Building real-time hydration tracking modules for LASIK in order to correct for hydration changes

詳細技術說明: Researchers at UCLA have developed an imaging system to detect corneal hydration levels by illuminating the cornea with low power, low energy, THz frequency light and measuring the magnitude of the reflected THz signal. The system is capable of resolving 0.18% changes in the water concentration of the cornea in vivo and results suggest a ~3x increase in dynamic range over ultrasound based pachymetry.

*Abstract: UCLA researchers in the Department of Bioengineering have created a novel imaging system that measures corneal hydration levels by utilizing terahertz (THz) frequency (100 GHz - 1 THz) sources and detectors.

*Applications

Detecting inflammation, immune response, edema or disease in the cornea
Building real-time hydration tracking modules for LASIK in order to correct for hydration changes

*Principal Investigation: Name: Jean-Louis Bourges
Department:

Name: Martin Culjat
Department:

Name: Warren Grundfest
Department:

Name: Jean-Pierre Hubschman
Department:

Name: Rahul Singh
Department:

Name: Zachary Taylor
Department:

Name: Priyamvada Tewari
Department:

附加資料: Patent Number: US20130162949A1
Application Number: US13597947A
Inventor: Culjat, Martin | Tewari, Priyamvada | Bourges, Jean L. | Hubschman, Jean P. | Singh, Rahul S. | Taylor, Zachary | Grundfest, Warren S.
Priority Date: 29 Aug 2011
Priority Number: US20130162949A1
Application Date: 29 Aug 2012
Publication Date: 27 Jun 2013
IPC Current: A61B000300
US Class: 351221 | 351246
Assignee Applicant: The Regents of the University of California
Title: CORNEAL HYDRATION SENSING SYSTEM
Usefulness: CORNEAL HYDRATION SENSING SYSTEM
Summary: Corneal hydration sensing system for measuring injury and disease extent such as traumatic injury, stromal edema and dystrophy. Can also be used in Fuch's dystrophy, ocular trauma, corneal graft rejection keratoconus and ablation control.
Novelty: Corneal hydration sensing system for measuring disease e.g. dystrophy, has signal processing system that processes detection signal to provide measure of amount of hydration sensed in cornea of subject

其他: State Of Development
DEVELOPMENT-TO-DATE: Researchers have created a working prototype and have successfully completed a preliminary in-vivo animal trials.
Background
Proper corneal hydration levels are critical to maintaining optical vision. Currently, corneal hydration is measured using ultrasound optical pachymetry, which involves measuring the central corneal thickness and extrapolating the average water content from these measurements. However, mapping from thickness to hydration is very inaccurate and is limited by inherent constraints. Another method uses confocal Raman spectroscopy to remotely measure corneal hydration. However, the excitation illumination influence necessary to achieve accurate measurements exceeds the ANSI regulations for use in humans by orders of magnitude.
Tech ID/UC Case
22577/2012-100-0

Related Cases
2012-100-0

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