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New Low-Cost Method for Pre-clinical Animal Imaging

技術優勢

Low-cost anatomical data assessment Requires no specialized staffing for operation Can be operated on a standard PC Convenience Can be operated within a laboratory bench-top Atlas registration after imaging takes less than 3 minutes on a standard PC Highly accurate

技術應用

Provide anatomical data for the functional imaging modalities, PET and SPECT (Single-photon emission computed tomography) Provide anatomical date for the optical imaging modalities, bioluminescence and fluorescence

詳細技術說明

Researchers at UCLA have developed a computerized approach to enable the estimation of 3 dimensional internal mouse anatomy from low-cost, non-tomographic, bench top imaging systems.

*Abstract

Researchers at the University of California, Los Angeles (UCLA) have developed an automated, highly accurate approach to acquire anatomical data from animal subjects in pre-clinical research. The invention provides a means to low-cost access of pre-clinical imaging.

*IP Issue Date

Dec 20, 2016

*Principal Investigation

Name: Arion Xenofon Hadjioannou

Department:

Name: Hongkai Wang

Department:

附加資料

Patent Number: WO2013019985A3
Application Number: WO2012US49389A
Inventor: WANG, Hongkai | HADJIOANNOU, Arion, F.
Priority Date: 3 Aug 2011
Priority Number: WO2013019985A3
Application Date: 2 Aug 2012
Publication Date: 23 May 2013
IPC Current: A61B000600
Assignee Applicant: The Regents of the University of California
Title: 2D/3D REGISTRATION OF A DIGITAL MOUSE ATLAS WITH X-RAY PROJECTION IMAGES AND OPTICAL CAMERA PHOTOS | ENREGISTREMENT EN DEUX DIMENSIONS (2D)/TROIS DIMENSIONS (3D) D'UN ATLAS NUMÉRIQUE DE SOURIS AVEC DES IMAGES DE PROJECTION PAR RAYONS X ET DES PHOTOS DE CA
Usefulness: 2D/3D REGISTRATION OF A DIGITAL MOUSE ATLAS WITH X-RAY PROJECTION IMAGES AND OPTICAL CAMERA PHOTOS | ENREGISTREMENT EN DEUX DIMENSIONS (2D)/TROIS DIMENSIONS (3D) D'UN ATLAS NUMÉRIQUE DE SOURIS AVEC DES IMAGES DE PROJECTION PAR RAYONS X ET DES PHOTOS DE CAMÉRA OPTIQUE
Summary: Method for preparing image simulating of anatomy of a small subject test animal i.e. laboratory mouse, for pre-clinical cancer research and drug development using non-tomographic imaging modalities e.g. optical cameras, three-dimensional surface scanners and bench-top planar X-ray systems.
Novelty: Method for preparing image simulating anatomy of laboratory mouse for pre-clinical cancer research and drug development using e.g. optical cameras, involves co-registering simulation with previously generated atlas of anatomy of animals

主要類別

診斷/治療

細分類別

癌症/腫瘤

申請號碼

9524552

其他

State Of Development

The researchers have developed a functional prototype.

Background

Translational and basic research on disease relies heavily on small animal imaging. Computed tomography (CT) and Magnetic Resonance Imaging (MRI) are frequently used in conjunction with Positron Emission Tomography (PET) to provide the anatomical data in pre-clinical research. However, wide use of CT and MRI is limited by their high costs and their need for specialized staff. In addition, their large size requires the dedication of valuable facility space and coordination of usage by many researchers. Therefore, there is need for affordable and convenient anatomical analysis of animal models. Computational registration of mouse anatomy has the potential to save research institutions considerable equipment and imaging expenses and reduce the time researchers expend on retrieving anatomical data. These advancements will expand research capacity by providing greater accessibility to pre-clinical imaging. Such a widespread expansion in pre-clinical imaging tools would especially accelerate research and drug development for cancer, neurodegenerative disease, autoimmunity, and metabolic disorders.

Related Materials

Mouse Atlas Registration with Non-tomographic Imaging Modalities-a Pilot Study Based on Simulation.

Additional Technologies by these Inventors

• Animal Imaging Chamber for Reproducible Positioning in Repetitive and Cross-platform Imaging
• A System For Vascular Access In Preclinical Models
• Copyright: A Statistical Atlas of the Mouse Trunk Region
• High Resolution Depth of Interaction Gamma Radiation Detector
• A Method for Obtaining Depth of Interaction in Pixelated Scintillator Detectors

Tech ID/UC Case

22108/2011-395-0

Related Cases

2011-395-0

國家/地區

美國