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Bioactivation and Surface Properties Modulation of Inorganic Nanoparticles

技術優勢: Allows for microparticles and nanoparticles to be used in biological systems in which they would ordinarily not be effective (i.e., semiconductor nanocrystals).

技術應用: Permits the use of inorganic, organic, metallic, and semiconducting nanoparticles in biological systems. Potentially useful for drug discovery, medical imaging, therapeutic reagents, self-assembly of nano-machines by molecular recognition, light-controlled enzymes and catalysts, and bio-mimetic materials.

詳細技術說明: The invention allows inorganic particles to be used in biological systems. By attaching specialized peptides to the surface of the particle, this invention allows these inorganic particles to take on biologically important functions. It provides water solubility and bioactivity to inorganic, metallic, and semiconducting nanoparticles as well as organic particles. The peptides also have a functional end that allows for adjusting the nanoparticles' targeting capabilities by way of interchangeable sequences. Thus, in line with the example above, this invention would permit the use of semiconductor nanocrystals as fluorescent labels in biological systems.

*Abstract: UCLA investigators have developed a method of allowing inorganic, metallic, and semiconductor particles to take part in biological systems. By attaching a specialized peptide to the surface of an inorganic nanoparticle such as a semiconductor nanocrystal, this invention gives non-biocompatible particles water solubility and bioactivity.

*Applications

Permits the use of inorganic, organic, metallic, and semiconducting nanoparticles in biological systems. Potentially useful for drug discovery, medical imaging, therapeutic reagents, self-assembly of nano-machines by molecular recognition, light-controlled enzymes and catalysts, and bio-mimetic materials.

*IP Issue Date: Aug 16, 2011

*Principal Investigation: Name: David King
Department:

Name: Fabien Pinaud
Department:

Name: Shimon Weiss
Department:

Name: Shimon Weiss
Department:

附加資料: Patent Number: US7998923B2
Application Number: US2003513567A
Inventor: Pinaud, Fabien | King, David | Weiss, Shimon
Priority Date: 7 May 2002
Priority Number: US7998923B2
Application Date: 3 Nov 2004
Publication Date: 16 Aug 2011
IPC Current: A61K003800 | A61K004748 | A61K005100
US Class: 5140011 | 42400169 | 530300
Assignee Applicant: The Regents of the University of California
Title: Bioactivation of particles
Usefulness: Bioactivation of particles
Summary: (II) is useful in producing a bioactivated particle, preferably bioactivated quantum dot that is soluble in an aqueous medium, which involves providing a particle that includes a surface or providing a quantum dot, treating the surface of the particle or the quantum dot with a sufficient amount of (II) to make the bioactivated nanoparticle or bioactivated quantum dot soluble in the aqueous medium (claimed). (I) (I) is useful in targeting, imaging and therapeutical applications. The bioactivation peptide of (I) is useful for semiconductor nanocrystals (NCs) fluorescent probe targeting, targeting of particles to tumors for X-ray medical imaging, for providing molecular recognition capabilities to the particles, and also in peptide library screening/phage display, in vivo / in vitro drug screening, in vivo / in vitro multicolor assays for application of quantum dots in atomic force microscopy (as probes), and assays based on peptide/peptide interaction, protease responsive sequence, peptide/DNA interaction, peptide/RNA interaction, molecular dynamic of antibody/antigen interactions by single molecule detection/quenching or single molecule fluorescence resonance energy transfer (FRET), crystallography two-dimensional, three-dimensional arrays for protein structure analysis, solid phase hybridization assay using quantum dots as a support, enzyme kinetic assays and peptide-nucleic acid (PNA) technology. The bioactivation peptides are useful in self-assembly of organic-inorganic nanostructure hybrids by molecular recognition, and in making interfacing enzymes, biocatalysts and other proteins/RNA catalysts to (II) nanoparticles to produce nanomachines/molecular machines that are activated by light and/or charge.
Novelty: Bioactivated particles useful in imaging and targeting applications, comprising a particle with a surface, and a bioactivation peptide comprising a surface recognition portion and functional portions, attached to the surface of the particle

主要類別: 生物醫學

細分類別: 醫學影像

申請號碼: 7998923

其他

Background

Use of inorganic microparticles and nanoparticles in biological systems may confer many benefits. One primary example is in the realm of fluorescent labeling as an analytical tool for modern biotechnology and analytical chemistry. Conventional labels that use organic dye molecules carry several limitations. Only a few different colors may be used simultaneously, they require a broad spectrum excitation source, their photostability is not very long, and it is impossible to label a material with a single type of probe for both electron microscopy and for fluorescence.

Semiconductor nanocrystals (also known as quantum dots) provide a very real solution to the limitations of organic dye molecules. Varying the size of the nanocrystals allows a tuning of the emission wavelength without changing the absorption characteristics. Further, they emit a strong fluorescent signal that remains stable for a much longer period of time. However, these semiconductor nanocrystals are highly hydrophobic particles. As a result, to have any significant biological application, surface chemistry is necessary to make the particle biocompatible and soluble in aqueous environments.

Related Materials

Bioactivation and Cell Targeting of Semiconductor CdSe/ZnS Nanocrystals with Phytochelatin-Related Peptides

Additional Technologies by these Inventors

Tech ID/UC Case

21728/2002-243-0

Related Cases

2002-243-0

國家/地區: 美國

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