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On-Demand Release of Guest Molecules by Using Mesoporous Silica Nanoparticles Equipped with Nanoimpellers

技術優勢

Higher efficacy achieved by specific targetingPrecise releaseSpatial and temporal external control

技術應用

Targeted therapyOn-demand release of:anti-cancer drugs (cancer therapy)anti-microbial drugs (i.e. dental treatment)anti-viral drugs (i.e. agriculture)

詳細技術說明

UCLA researchers have successfully developed a nanoimpellar based nanoparticle to transport molecules into living cells and have demonstrated both temporal and site-specific release under photo-activation. These nanoparticles are avidly taken up in vitro and have demonstrated specific photo-controlled release of both fluorescent dyes and apoptosis inducing cancer drugs in cell lines of both pancreatic and colon cancer. This invention represents a novel approach for external control of drug release, and has very strong potential in a number of applications.

*Abstract

UCLA inventors have developed a novel approach to site specifically release molecules into living cells using a silica-based nanoparticle that functions as a sealed container. This nanoparticle is readily taken up into cells and contains a photo-triggered impellar that once activated, will result in release of its contents. This unique approach to drug delivery holds strong promise for a number of applications including cancer therapy, as well as antibiotic, and anti-viral drug delivery.

*Applications

• Targeted therapy
• On-demand release of:
  • anti-cancer drugs (cancer therapy)
  • anti-microbial drugs (i.e. dental treatment)
  • anti-viral drugs (i.e. agriculture)

*IP Issue Date

Apr 6, 2017

*Principal Investigation

Name: Sarah Henscheid

Department:

Name: Eunshil Choi

Department:

Name: Sanaz Kabehie

Department:

Name: Jie Lu

Department:

Name: Andre Nel

Department:

Name: Fuyuhiko Tamanoi

Department:

Name: Jeffrey Zink

Department:

附加資料

Patent Number: US20100284924A1
Application Number: US2010812359A
Inventor: Zink, Jeffrey I. | Tamanoi, Fuyuhiko | Choi, Eunshil | Angelos, Sarah | Kabehie, Sanaz | Nel, Andre | Lu, Jie
Priority Date: 23 Jan 2008
Priority Number: US20100284924A1
Application Date: 9 Jul 2010
Publication Date: 11 Nov 2010
IPC Current: A61K000914 | A61K000802 | A61K004900 | A61P003500 | A61P004300 | A61Q009000 | B32B000500
US Class: 4240091 | 424401 | 424489 | 428402
Assignee Applicant: The Regents of the University of California
Title: NANO-DEVICES HAVING IMPELLERS FOR CAPTURE AND RELEASE OF MOLECULES
Usefulness: NANO-DEVICES HAVING IMPELLERS FOR CAPTURE AND RELEASE OF MOLECULES
Summary: Nano-device for capturing and release of molecules in fluidics and drug delivery, and used for biological and biomedical applications.
Novelty: Nano-device for capturing and release of molecules in e.g. fluidics, has impeller that is attached to containment vessel for loading, unloading or containing molecules in containment vessel

主要類別

生物醫學

細分類別

醫療裝置

申請號碼

20170095418

其他

Background

With targeted drug delivery, the overall goal is to restrict treatment to a specific subset of cells. This approach would both reduce off target cytotoxicity and vastly enhance the efficacy of drug treatment. Towards this end, a number of approaches have been developed with varied success. Recently, nanoparticles have shown great promise as drug delivery vehicles due to their flexibility, scalability, and ease of use. Through use of a light-activated, mesoporous, silica nanoparticle, researchers at UCLA have developed an innovative trap and release scheme that will allow for precise control of drug delivery. The use of a photo-controlled agent for targeted drug delivery has not been demonstrated up to this point.

Related Materials

Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells

Additional Technologies by these Inventors

• Novel Non-Peptidomimetic Prenyl Transferase Inhibitors

Tech ID/UC Case

21563/2008-232-0

Related Cases

2008-232-0

國家/地區

美國