Mouse Model for Conditional Knockout of the PTEN Gene
- 技術應用
- Examination of the role of PTEN expression in any mouse model where CRE-recombinase can be conditionally expressed
- 詳細技術說明
- UCLA Researchers have developed a mouse model in which the PTEN gene can be conditionally knocked out. This model can be applied to inhibit the expression of PTEN via crossing of mice bearing tissue or condition-specific expression of the CRE-recombinase, allowing for subsequent conditional ablation of PTEN expression.
- *Abstract
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None
- *Principal Investigation
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Name: Ralf Lesche
Department:
Name: Xin Liu
Department:
Name: Hong Wu
Department:
- 其他
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Background
PTEN has been shown to be central in the regulation of cellular growth and survival. In many forms of cancer, mutations or loss of function in PTEN results in tumor formation - and as such PTEN is now appreciated as a central player in tumor suppression. Furthermore, PTEN has been shown to have a modulating role on cellular functions other than growth and survival, implicating this protein in diseases such as diabetes. Therefore, examination of PTEN in other models of disease may provide insight towards the understanding of mechanism and treatment of these diseases.
Additional Technologies by these Inventors
Tech ID/UC Case
20413/2008-020-0
Related Cases
2008-020-0
- 國家/地區
- 美國
