New Therapeutic Leads for Cachexia and Anorexia
Stimulates feeding for more than six days after a single injectionStimulates feeding longer than all other known hormones/drugs
Therapeutic treatment for extreme cases of eating disorders such as anorexia or cachexia
UCSC researchers have previously isolated the specific region of AgRP that is required to bind to the MC receptors. New studies show regions adjacent to those that make receptor contact are critical for AgRP's long lasting activity. UCSC researchers have now designed reliable non-natural proteins where they can greatly extend the time over which a single AgRP injection stimulates feeding. Normally, AgRP stimulates feeding over one to three days. Here the newly designed protein stimulates feeding for up to six days. Moreover, the cumulative food intake stimulated by UCSC’s designed AgRP is approximately double that of other appetite stimulating proteins. The animal models demonstrate an increase in body weight by 15% in a one week period, compared to 5% in animals treated with wild type AgRP.
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Related Materials Tech ID/UC Case 22013/2011-318-0 Related Cases 2011-318-0
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