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Oxidative Biomarkers in Predicting Risk of Stroke and TIA

詳細技術說明: Using a population-based prospective 15 year cardiovascular and stroke risk outcomes the researchers were able to demonstrate the clinical value of oxidation-specific biomarkers as predictors of cardiovascular events and stroke. Individually, one set of markers predicted a higher event rate, whereas another set of markers predicted a lower event rate. Since there are very few biomarkers for predicting stroke, laboratory assays with strong predictive value are certainly needed. The use of OxPL/apoB assay and other markers related to OxLDL to predict risk of stroke and TIA was previously not known. Oxidation specific epitopes have been shown here to predict CVD and stroke outcomes and provide clinical utility by reclassifying individuals into higher or lower risk categories.

*Principal Investigation: Name: Sotirios Tsimikas
Department:

Name: Joseph Witztum
Department:

附加資料: Patent Number: WO2014018643A1
Application Number: WO2013US51839A
Inventor: TSIMIKAS, Sotirios | WITZTUM, Joseph, L.
Priority Date: 24 Jul 2012
Priority Number: WO2014018643A1
Application Date: 24 Jul 2013
Publication Date: 30 Jan 2014
IPC Current: G01N003368 | G01N003348 | G01N003353
Assignee Applicant: The Regents of the University of California
Title: OXIDATIVE BIOMARKERS IN PREDICTING RISK OF STROKE, TRANSIENT ISCHEMIC ATTACK (TIA) AND PERIPHERAL ARTERIAL DISEASE (PAD) | BIOMARQUEURS OXYDATIFS DANS LA PRÉDICTION DU RISQUE D'ACCIDENT VASCULAIRE CÉRÉBRAL, D'ATTAQUE ISCHÉMIQUE TRANSITOIRE (TIA) ET D'UNE
Usefulness: OXIDATIVE BIOMARKERS IN PREDICTING RISK OF STROKE, TRANSIENT ISCHEMIC ATTACK (TIA) AND PERIPHERAL ARTERIAL DISEASE (PAD) | BIOMARQUEURS OXYDATIFS DANS LA PRÉDICTION DU RISQUE D'ACCIDENT VASCULAIRE CÉRÉBRAL, D'ATTAQUE ISCHÉMIQUE TRANSITOIRE (TIA) ET D'UNE MALADIE ARTÉRIELLE PÉRIPHÉRIQUE (PAD)
Summary: The method is useful for determining a risk of stroke, a TIA or PAD in a subject (claimed).

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