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Methods For Diagnostic Techniques And Diagnosis Of Multiple Sclerosis, Autoimmune Disorders And Diseases Related To Glycan Dysregulation

技術優勢: Versatile diagnostic and monitoring method: § Can be applied to many types of glycan-related diseases and disorders to identify and quantify biomarkers § Can monitor treatments that include the described and related metabolites as medications Efficient and accessible: -The approach is simple, easy to perform, and produces results rapidly -Utilizes common lab instrumentation, liquid chromatography-mass spectrometry

技術應用: .Diagnose, identify and analyze diseases associated with glycan dysregulation: Multiple Sclerosis, Type I and Type II Diabetes, Cancer .Utilize methods in a clinical setting to determine disease status and efficiency of therapeutics .Guide treatment options and strategies .Monitor therapies and medications

詳細技術說明: Multiple Sclerosis (MS) is a highly prevalent autoimmune disorder, affecting 400,000 people per year in the US. There is no specific test for MS, thus it is typically diagnosed by ruling out other diseases and disorders using an array of tests, including expensive or invasive procedures, such as brain imaging and lumbar punctures. Researchers at UCI have determined that specific metabolites that are present in healthy human serum and influence protein glycosylation, including Uridine and G1cNAc, are deficient in individuals with MS, leading to dysregulation of glycosylation. They have developed a mass spectroscopy assay to be used as a novel diagnostic test for Multiple Sclerosis. The technique assesses the composition of human serum for key metabolites associated with the disease. Unlike other diagnostic methods, this assay is noninvasive, quantitative, and highly sensitive. Furthermore, this research and assay may be applicable for the diagnosis or prevention of related disorders with underlying defective protein glycosylation.

*Abstract: Certain diseases, such as Multiple Sclerosis and other autoimmune disorders, are associated with deficiencies in specific metabolites that influence protein glycosylation. This invention is a specialized method to detect levels of these metabolites, which can then be used to diagnose disorders and guide personalized treatments.

*Principal Investigation: Name: Micheal Demetriou
Department:

Name: James Dennis
Department:

Name: Alexander Brandt
Department:

Name: Paul Friedmann
Department:

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