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Triple Transgenic Mouse Model of Alzheimer's Disease

詳細技術說明: University of California, Irvine researchers have developed a novel transgenic mouse model that contains the three major genes that contribute to the hallmark pathological features of Alzheimer's disease. These mice are exceedingly valuable for therapeutic investigations and for basic research aimed at understanding the behavioral, physiological, molecular/cell biological, and pharmacological processes leading to dementia in an animal model. Even though these mice contain three transgenes, the mice essentially breed as readily as a "single" transgenic line, greatly facilitating the establishment and maintenance of an animal colony.

附加資料: Patent Number: US7479579B2
Application Number: US2003499269A
Inventor: LaFerla, Frank M.
Priority Date: 20 Dec 2001
Priority Number: US7479579B2
Application Date: 8 Sep 2004
Publication Date: 20 Jan 2009
IPC Current: A01K0067027 | G01N003300 | A01K0067033 | A61K004500 | A61P002528 | C07K001447 | C12N001500 | C12N001509 | C12N001585 | G01N003315 | G01N003350
US Class: 800012 | 800003 | 800022
Assignee Applicant: The Regents of the University of California
Title: Triple transgenic mouse model of Alzheimer's disease
Usefulness: Triple transgenic mouse model of Alzheimer's disease
Summary: The transgenic animals are useful as models for human diseases, particularly Alzheimer's disease. These animals are also useful for screening biologically active agents for use in treating and/or ameliorating AD or AD-type pathologies. These animals are also useful for assessing the efficacy of anti-Aβ therapies in mitigating synaptic dysfunction and tau-mediated neurodegeneration.
Novelty: New triple transgenic mouse with transgenes encoding mutated human presenilin-1, Tau and amyloid precursor proteins, useful as models for human Alzheimer's disease (AD), or for screening agents for treating AD(-type) pathologies

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