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New Anti-Microbial and Anti-Biofilm Silicone Formulation

技術應用: The new silicone formulation may be useful for urinary tract stents, catheters, and nephrostomy tubes. In addition, it may possibly be of value in the development of a prosthetic bladder material for partial or eventually even total replacement of the bladder.

詳細技術說明: Scientists and physicians at the University of California, Irvine have developed a new silicone formulation that appears to be resistant to encrustation and biofilm formation during in vitro testing. Further in vivo studies are in progress.

*Abstract: Recurrent blockage of urinary catheters and indwelling ureteral stents made of silicone and other materials is a common problem. Blockage is frequently caused by the build-up of precipitated mineral deposits (i.e. encrustations) on the catheter or stent surface. In addition, various bacteria in the urine can adhere to the surface and create a protective biofilm thereby precluding effective antibiotic therapy and further contributing to mineral deposition.
The problem of biofilm and encrustation has been approached by developing anti-microbial coatings or the inclusion of organic anti-microbial components into the substance of the stent itself. However none of these anti-microbial techniques is completely effective.

*Principal Investigation: Name: Ralph Clayman
Department:

Name: Yuan-Chang Lin
Department:

Name: Yeongher Lin
Department:

Name: Michael Louie
Department:

Name: Frank Shi
Department:

附加資料: Patent Number: US8257827B1
Application Number: US13151704A
Inventor: Shi, Frank | Clayman, Ralph | Louie, Michael K. | Lin, Yeong-Her | Lin, Yuan-Chang
Priority Date: 2 Jun 2011
Priority Number: US8257827B1
Application Date: 2 Jun 2011
Publication Date: 4 Sep 2012
IPC Current: B32B000516
US Class: 428328 | 524403
Assignee Applicant: The Regents of the University of California
Title: Silicone composition and devices incorporating same
Usefulness: Silicone composition and devices incorporating same
Summary: The method is useful for forming silicone having anti-microbial properties (claimed) which is useful in medical devices e.g. catheters, diaphragms, seals in dialysis equipment, brain surgery-related products, cosmetic and repair parts, heart surgery-related products, medical tubing, ureteral stents, urinary bladder catheters, nephrostomy tubes and an artificial urinary bladder/reservoir.
Novelty: Forming silicone having anti-microbial properties, used in medical devices e.g. catheters, comprises e.g. adding silica and nanoparticles to liquid vinyl-terminated polydimethylsiloxane and adding coupling agent to above mixture and heating

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