Novel Impact Of Mir34a For The Reprogramming Of Cells
- 詳細技術說明
- None
- *Abstract
-
Somatic cells can be induced to generate pluripotent stem cells that functionally resemble embryonic stem cells (ES cells). This reprogramming process, rooted in the remarkable cellular plasticity retained during differentiation, can be triggered by exogenous expression of a set of ES-cell specific gene regulators. However, reprogramming occurs with low efficiency and slow kinetics using the current technologies, reflecting our lack of in-depth mechanistic understanding of this process. At present, among the best-characterized reprogramming factors are a defined set of transcriptional regulators, Oct4 and Sox2, Klf4 and c-Myc. Most of these factors constitute integral components of the core gene regulatory circuits that coordinately control pluripotency and self-renewal in pluripotent stem cells.
miRNAs are a large family of small non-coding RNAs that primarily repress gene expression by pairing with partially complementary mRNA targets. The small size of miRNAs, combined with their imperfect target recognition, gives them enormous capacity and versatility to regulate global gene expression.
This technology describes how specific miRNAs can be used to reprogram cells to generate pluripotent stem cells.
- *IP Issue Date
- Sep 15, 2015
- *Principal Investigation
-
Name: Yong Jin Choi
Department:
Name: Greg Hannon
Department:
Name: Lin He
Department:
Name: Xingyue He
Department:
Name: Chao-Po Lin
Department:
- 附加資料
- Patent Number: US20130020207A1
Application Number: US13185939A
Inventor: Shao-Horn, Yang | May, Kevin | Suntivich, Jin
Priority Date: 19 Jul 2011
Priority Number: US20130020207A1
Application Date: 19 Jul 2011
Publication Date: 24 Jan 2013
IPC Current: C25B000102 | C25B000900 | C25B001106 | H01M000488
US Class: 205635 | 204242 | 502101
Title: Electrochemical Methods and Systems Using Catalytic Materials
Usefulness: Electrochemical Methods and Systems Using Catalytic Materials
Summary: Electrochemical system is used for generating oxygen (claimed) for metal-air battery.
Novelty: Electrochemical system for generating oxygen, has electrodes, electrolyte and voltage source, and is configured such that catalyst catalyzes oxygen evolution reaction when oxygen-generating voltage is applied across electrodes
- 主要類別
- 生物醫學
- 細分類別
- 生物工程
- 申請號碼
- 9132152
- 其他
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Additional Technologies by these Inventors
Tech ID/UC Case
21261/2011-076-0
Related Cases
2011-076-0
- 國家/地區
- 美國
