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Portable Fluorescence Detection Microsystem Based On Si Semiconductors

技術優勢: Compact, portable design for field applications.Hygienic separation of disposable and nondisposable components for fast sequential testing.Integration of multicolored LEDs with matching filters for simultaneous bioassay or chemical detection processing.Lower costs fabrication for conventional lab applications.

技術應用: Patient medical assessments in civilian or military situations where quick, field analysis is critical.Environmental detection of chemical and biological agents such as anthrax and endotoxin.

*Abstract: Fluorescence detection is widely used as a bioassay technique in laboratories. If this technique could be functionally?integrated in a microsystem format, then its lower cost and improved portability would broaden the applications of fluorescence for both bioassay and chemical detection in the field as well as in the lab.
To address this opportunity, researchers at the University of California at Berkeley have developed a microsystem and corresponding fabrication process that integrates photodetection, filtering and excitation. This Si-based microsystem performs the same functions as a bench-top fluorescence detection system by replacing the bench-top system's gas laser with a thin-film LED, and replacing the bench-top's grating, bulk glass and/or DBR filter with a single-layer thin-film filter.
In comparison to bench-top systems, this fluorescence detection microsystem is less expensive and more compact, making it better-suited to applications in the field. The Berkeley microsystem combines all of its nondisposable components on a single substrate, and hygienically isolates its disposable microfluidic component, enabling the device to sequentially evaluate many samples. Moreover, multicolored LEDs with matching filters can be integrated in a single microsystem, enabling it to simultaneously perform multiple bioassays and chemical detections.

*Principal Investigation: Name: J. Alex Chediak
Department:

Name: Nathan Cheung
Department:

Name: Luke Lee
Department:

Name: Zhongsheng Luo
Department:

Name: Timothy Sands
Department:

Name: Jeonggi Seo
Department:

附加資料: Patent Number: US7221455B2
Application Number: US2004903477A
Inventor: Chediak, J. Alex | Luo, Zhongsheng | Sands, Timothy D. | Cheung, Nathan W. | Lee, Luke P. | Seo, Jeonggi
Priority Date: 20 Jan 2004
Priority Number: US7221455B2
Application Date: 30 Jul 2004
Publication Date: 22 May 2007
IPC Current: G01N002125 | G01J000158 | G01N002105 | G01N002164
US Class: 356419 | 2504581 | 2504591 | 356417 | 42208208 | 436172
Assignee Applicant: The Regents of the University of California
Title: Integrated, fluorescence-detecting microanalytical system
Usefulness: Integrated, fluorescence-detecting microanalytical system
Summary: The invention deals with a light source and detector for an integrated (multiwavelength) microanalytical system (claimed) that is useful for performing fluorescence spectroscopy. The invention is useful in the fields of e.g. spectroscopic detection, identification and/or characterization of substances, fluorescence detection, and identification and/or characterization performed by an integrated microanalytical system.
Novelty: Light source and detector for integrated microanalytical system, comprises a light source (producing exciting radiation) that directs the radiation onto sample; and a detector (detecting the radiation) that receives radiation from sample

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