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Facile gas-induced transformation of pharmaceutical polymorphs/organic solids

*Abstract: Gas pressurization can be used to convert polymorphs of pharmaceutical agents with ease. Current processing methods are often lengthy and can involve the use of high temperature at great expense to the industrial sector. Our facile method of polymorph transformation eliminates the need for such measures, and offers vast potential for streamlining the processing of pharmaceutical agents, with a concomitant savings in energy costs while potentially creating new pharmaceutical entities and patent extensions. POTENTIAL AREAS OF APPLICATION:• Pharmaceutical manufacturingMAIN ADVANTAGES OF INVENTION:• Establishing new drug entities; potentially extending patent lifeCost savings and improved efficiency STAGE OF DEVELOPMENT:• Demonstrated with several marketed drugsPATENT STATUS:• Patent pending• See J Am Chem Soc. 2011 Feb 9;133(5):1399-404. Epub 2011 Jan 5.CONTACT INFO:Paul Hippenmeyer, Sr. Licensing & Business Development AssociateOffice of Technology Management and Industry Relations Email: hippenmeyerp@missouri.edu Phone: 573-882-0470

*Principal Investigation: Name: Jerry Atwood, Curators' Professor and Chair
Department:

Name: Jian Tian, Pstdoctoral Research Associate
Department:

Name: Scott Dalgarno, Reader - Inorganic Chemistry
Department:

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