Modulation of sphinogosine 1-phosphate-metabolizing enzymes for the treatment of influenza
- 標題
- MODULATION OF SPHINGOSINE 1-PHOSPHATE METABOLIZING ENZYMES FOR THE TREATMENT OF NEGATIVE-STRAND RNA VIRUS INFECTIONS
- 詳細技術說明
- None
- *Abstract
-
Influenza virus continues to cause tremendous morbidity and mortality on an annual basis. While vaccines exist to help prevent infection, there are only a handful of drugs approved for treating the infected individual. Moreover, the virus has evolved, in many cases, to become resistant to these treatments. The current discovery identifies sphingosine-1-phosphate pathway as critical for virus replication. Blocking sphingosine kinase activity or over expressing sphingosine 1-phosphate lyase strongly inhibited virus propagation. Therefore, modulation of this pathway could lead to new points of pharmaceutical intervention.Potential areas of application:Inhibit influenza virus replicationAdvantages:Fresh target for pharmaceutical interventionComplements current drug mechanisms of action Stage:PreclinicalPatent status:Provisional filedSee J Virol. 2010 Aug;84(16):8124-31. Epub 2010 Jun 2 Paul Hippenmeyer, Ph.D., M.B.A.Senior Licensing and Business Development AssociateOffice of Technology Management and Industry RelationsN512 Health Sciences Building DC18.00University of Missouri-Columbia 65212Phone: 573-882-0470Fax: 573-884-2465
- *IP Issue Date
- Jun 27, 2017
- *Principal Investigation
-
Name: Bumsuk Hahm, Prof, Asoc
Department:
Name: Young-Jin Seo, Postdoctoral Fellow
Department:
Name: Stephen Alexander, Professor Emeritus of Biological Science
Department:
Name: Madhuvanthi Vijayan, Research Specialist - SR
Department:
- 申請日期
- Nov 26, 2013
- 申請號碼
- 9,687,477
- 其他
-
- 國家/地區
- 美國
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