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BioNanoComposite for Tissue Regeneration and Soft Tissue Repair

詳細技術說明

None

*Abstract

Bionanocomposite for Soft Tissue RepairImplanted biomaterials utilized for soft tissue repair suffer from poor tissue integration, which permits sliding and rubbing of the material on the cells and tissues. This lack of control at the biomaterial tissue interface results in repeated cellular injury and chronic inflammatory response, thus leading to decreased function, chronic pain, and eventual implant removal. New soft tissue repair materials have utilized collagen scaffolds, but purified collagen is mechanically weak and chemically cross linked collagen has inadequate biocompatibility.The current invention developed by researchers at the University of Missouri is a mesh that achieves a higher level of control at the interface between the tissue and the implant, which translates into improved tissue integration and overall biocompatibility. The fabrication from novel bionanocomposite is relatively inexpensive, faster than conventional methods, and utilizes non-toxic, water soluble cross-linking agents.POTENTIAL AREAS OF APPLICATIONS- Hernia repair- Meniscus tissue replacement- Cardiovascular patchesMAIN ADVANTAGES OF INVENTION- Superior soft tissue replacement- Improved tissue integration and biocompatibility- Completely resorbable - Degradation rate can be controlled - Reduced recurrence rates STATE OF DEVELOPMENT: Prototype has been fabricatedLICENSING POTENTIALUniversity seeks licensee with potential to commercializePATENT STATUS: Patent application filedTECHNOLOGY INNOVATORSSheila A. Grant, Bruce Ramshaw, Sharon Bachman, Corey Renee CostelloTECHNOLOGY MANAGER CONTACTHarriet F. Francis, MS, JD; francish@missouri.edu; 573-884-0374

*Principal Investigation

Name: Sheila Grant, Professor

Department:

Name: Bruce Ramshaw

Department:

Name: Sharon Bachman

Department:

Name: Corey Deeken

Department:

Name: Nicole Fearing

Department:

Name: Archana Ramaswamy

Department:

其他

國家/地區

美國