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RAPID METHOD FOR SCREENING NOVEL CHEMICALS FOR USE IN CANCER THERAPY AND PREVENTION

標題

METHODS OF SCREENING NOVEL AGENTS FOR USE IN CANCER THERAPY AND PREVENTION

詳細技術說明

None

*Abstract

Chemotherapy is a widely used and effective form of treatment for many types of human cancers. However, a relatively small number of effective chemotherapeutic agents are available, and their use is complicated by the development of drug resistance by the tumors being treated. Currently, potential chemotherapy drugs are screened initially for their effect on the growth of human or murine tumor cells in culture. This type of screen is expensive, time consuming, and does not provide information on the mode of action of the drug. The current invention developed by researchers at University of Missouri is a method employing the model organism Dictyostelium discoideum for rapid and inexpensive screening of large numbers of compounds for their ability to damage DNA as assessed by the induction of DNA repair enzymes. Simultaneous determination of cell viability allows for the identification of novel drugs with anti-cancer activity.POTENTIAL AREAS OF APPLICATIONSØ Discover chemotherapy drugs that induce DNA damage but not DNA repairØ Discover chemotherapy drugs with no effects on DNA and DNA repairØ Discover chemotherapy potentiators that suppress DNA repairØ Discover cancer preventing drugs that induce DNA repair enzymes without damaging DNAMAIN ADVANTAGES OF INVENTIONØ Fast, simple, and inexpensiveØ Does not involve animals or animal cellsØ Provides information on mechanism of action of drugsØ Simultaneous monitoring of cell viability and induction of DNA repairSTATE OF DEVELOPMENTConcept has been tested using known cancer drugsLICENSING POTENTIALUniversity seeks licensee with potential to commercializePATENT STATUS: US patents 6,746,843 and 6,867,034TECHNOLOGY INNOVATORSHannah Alexander, Stephen AlexanderTECHNOLOGY MANAGER CONTACTHarriet F. Francis, MS, JD; francish@missouri.edu; 573-884-0374Per Stromhaug, PhD, MBA; stromhaugpe@missouri.edu; 573-884-3553

*IP Issue Date

Jun 8, 2004

*IP Publication Date

Apr 11, 2002

*Principal Investigation

Name: Hannah Alexander, Adjunct Associate Professor

Department:

Name: Stephen Alexander, Professor Emeritus of Biological Science

Department:

申請日期

Jul 25, 2001

申請號碼

6,746,843

其他

國家/地區

美國