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Real-Time Fluorescence Lifetime Tracking

技術優勢

Real-time analysis Rapid and non-invasive real-time tissue diagnosis Continuous acquisition, processing, and display Single hand held or biopsy fiber-optic probe Less sensitive to the presence of endogenous absorbers

技術應用

Tissue characterization Diagnosis in: Ophthalmology, cardiology, and oncology

詳細技術說明

Conventional imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) provide surgeons with a great deal of information about a tumor’s anatomy but cannot distinguish between cancerous and non-cancerous cells. Time-resolved fluorescence spectroscopy (TRFS) has shown promise in the imaging of biopsies of brain tumor, oral carcinoma, and atherosclerosis but currently requires a minimum of several seconds (and up to a few minutes) of off-line fluorescence decay analysis due to the large number of data points collected. While such an approach show-cases the potential of TRFS, it also presents a hurdle which prevents TRFS from being used as a real-time tissue diagnostic tool. Researchers at the University of California, Davis have developed a novel technique for continuous acquisition, processing, and display of fluorescence lifetimes. This technique allows for rapid and non-invasive real-time tissue diagnosis through a single hand held or biopsy fiber-optic probe. TRFS has been found to be less sensitive to the presence of endogenous absorbers (such as blood) or changes in light excitation collection.

*Abstract

Researchers at the University of California, Davis have developed a novel technique for continuous acquisition, processing, and display of fluorescence lifetimes. This technique allows for rapid and non-invasive real-time tissue diagnosis through a single hand-held or biopsy fiber-optic probe.

*IP Issue Date

Jul 28, 2016

*Principal Investigation

Name: Julien Bec

Department:

Name: Dinglong Ma

Department:

Name: Laura Marcu

Department:

Name: Diego Yankelevich

Department:

Name: Dimitrios Gkorpas

Department:

其他

Additional Technologies by these Inventors

• Single Fiber-Based Multimodal Biophotonic Imaging and Spectroscopy Platform
• Nondestructive System for Quantitative Evaluation of Cartilage Degradation and Regeneration
• Fabrication Method for Side Viewing Miniature Optical Elements with Free-Form Surface Geometry

Tech ID/UC Case

24902/2015-065-0

Related Cases

2015-065-0

國家/地區

美國