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Biomimetic approach to deposit bone-like coating on PEEK and other materials to improve osteoconductivity in implants

詳細技術說明

Project ID: D2011-33IP Status: Patent Pending U.S and EuropeInvention Description: Novel method to prepare an implantable article comprised of a biocompatible substrate (polymeric or ceramic) to accept a very thin biocompatible, bioactive coating material to facilitate bio-ingrowth between the substrate and bone or cartilage tissue.Applications: Bone fractures treated with wires, nails, screws, and plates; joints replaced by artificial endoprostheses; dental implants; other.Novelty: Uses microwave energy to form a carbonated calcium deficient hydroxyapatite (CDHA) layer on the surface of implants to solve problems inherent to materials for implants produced from metals, polymers, ceramics and calcium phosphates (CaP).  Value Proposition:•       BIOACTIVE + BIOCOMPATIBLE: Technology produces a biocompatible and bioactive form of calcium phosphate coating which will degrade and facilitate bone formation for faster patient healing and recovery.•       VERSATILE: Efficiently coats polymers and other substrates.•       FASTER PROCESSING TIME: Commercially efficient processing time. Newly developed technology performs the coating process within minutes to a few hours thus allowing for converting the batch process to a continuous process.•       THIN: Coating is very thin so as not to introduce fatigue under tensile loading or create residual stress, releasing energy which may promote interfacial debonding or flaking.•       Forms direct bonds to newly formed bone tissue in the body; •       Features biochemical and biomechanical properties suitable for load bearing orthopedic implants; •       No degradation in-vivo; •       Limited animal data is available.

*Abstract

*Principal Investigation

Name: Vijay Goel, Professor

Department: Bioengineering

Name: Sarit Bhaduri, Professor

Department: MIME

Name: Huan Zhou, Graduate Student

Department: Bioengineering

國家/地區

美國