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"Sweet-P": Molecule for Targeting Human Glucocorticoid Receptor Beta in Cancer

詳細技術說明

Project ID: D2016-49 IP Status: PCT patent application filed       Invention Description and Novelty: GRβ has been shown to increase growth and migration of cancer cells. Newly designed molecule suppresses GRβ to inhibit expression and migration of the cancer. Sweet-P is the only compound that has been shown to regulate GRβ. Applications: Treating GRβ-related diseases including bladder cancer, prostate cancer, lung cancer, leukemia, glioblastoma, liver cancer, breast cancer, lupus, and asthma, and methods for hindering migration of such cancers. Value proposition: •       Compositions and methods for treatment of GRβ-related diseases; •       Reduced to Practice: (1)       Sweet-P blocks GRβ expression in lung and prostate cancer cells, and (2)       Sweet-P blocks GRβ expression and migration of bladder cancer cells;•       Also included is a kit for preparing a pharmaceutical composition;•       No special method needed--Sweet-P can be synthesized through any method suitable for PNA synthesis.•       Ready for commercialization and will not require an expensive and lengthy product development period.

*Abstract

*Principal Investigation

Name: Terry Hinds, Assistant Professor

Department: Physiology & Pharmacology

Name: Lucien McBeth, Graduate Student

Department: Physiology & Pharmacology

國家/地區

美國