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A Small Peptide Inhibitor of Calcium Current

詳細技術說明: Herein we disclose embodiments of compositions and methods, particularly involving short peptides, which are capable of regulating calcium channel function.

*Abstract: Calcium channels can be regulated by natural gamma proteins. Herein we disclose embodiments of compositions and methods, particularly involving short peptides, which are capable of regulating calcium channel function. Certain short peptides which can inhibit calcium current have structural features from the first transmembrane domain of gamma6 such as a GxxxA motif and adjoining aliphatic residues. In embodiments, the peptide compositions and methods are capable of selective efficacy for low voltage-activated calcium channels, such as LVA channel Cav3.1, versus high voltage-activated channels.
For more information about this technology, please contact the University of Illinois at Urbana-Champaign at otm@illinois.edu.

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