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Accelerated Dissolution Rate of Pharmaceuticals

總結: Researchers at Purdue University have developed a novel approach to overcome the problems of high load, stable solid dispersions. This method, an intimate co-processing of the drug and an excipient, allows smaller-sized particles to dissolve faster while forming a crystalline physical mixture. This procedure enhances the dissolution rate and bioavailability of poorly soluble pharmaceutical compounds, using well-established equipment and methods. The formulated drug exists in a crystalline state, making it thermodynamically stable and far more storable than amorphous formulations. This concept is applicable to many drugs and has already been proven using three different drugs well known for their dissolution-related issues.

技術優勢: Enhances dissolution rate and bioavailability of poorly soluble drugsStorage of crystalline form is far superior Applicable to many drugs and uses well-established equipment and procedures

*Background: A typical approach to improve the bioavailability of poorly soluble pharmaceutical drugs involves the creation of solid dispersions by dissolving drugs in a water-soluble matrix. These solid dispersions; however, present major drawbacks as they can only manage a low drug load and the materials are inherently unstable. A major body of pharmaceutical research has focused on the development of delivery strategies that significantly enhance the dissolution of poorly soluble drugs, but lack the stability problems of amorphous solid dispersions.

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipRodolfo PinalPinal LabPurdue Industrial and Physical Pharmacy

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