亞洲知識產權資訊網為知識產權業界提供一個一站式網上交易平台,協助業界發掘知識產權貿易商機,並與環球知識產權業界建立聯繫。無論你是知識產權擁有者正在出售您的知識產權,或是製造商需要購買技術以提高操作效能,又或是知識產權配套服務供應商,你將會從本網站發掘到有用的知識產權貿易資訊。

Nanoparticle-Based Reagent for DNA and mRNA Detection

技術優勢
Enhancedphotostability and selectivity Decreasedbackground autofluorescenceLonger luminescencelifetimeNo transfectionreagents required
詳細技術說明
Novel, highly sensitive reagent for detection of double stranded DNA in living cells #nanotechnology #nanoparticles #manufacture/processes #researchtool #reagent
*Abstract

Northwestern scientists have developed a new reagent for detection of double stranded DNA in cells based on the well-known ruthenium DNA intercalator. Detection of specific genetic elements in live cells is key to understanding the onset and development of various human diseases. While several reagents to accomplish this already exist, many of them suffer from selectivity or detection issues, in addition to requiring toxic transfection reagents for intracellular delivery. This novel detection reagent from Prof. Mirkin's group can enter cells without transfection reagents, is more selective and specific for double stranded DNA than current alternatives and its fluorescence is completely quenched before the target sequence is identified. Further, this reagent could also be used for mRNA detection, localization and quantification, which may lead to development of innovative drug screening platforms.

*Inventors
Chad Mirkin*Chad ShadeRobert Kennedy
國家/地區
美國

欲了解更多信息,請點擊 這裡
移動設備