Aptamer-Loaded, Biocompatible Nanoconstructs for Nuclear-Targeted Cancer Therapy
- 技術優勢
- High concentration of drug molecules stabilized on the nanoconstruct Low nanoconstruct aggregationLight-triggered controlled release of drug molecules
- 詳細技術說明
- A gold-based nanoconstruct for the timed, targeted delivery of cancer therapeutics.#therapeutics #cancer #drugdelivery
- *Abstract
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Northwestern researchers have developed a nanoconstruct composed of gold nanostars (AuNSs )loaded with nucleolin-specific aptamers for nuclear-targeted cancer therapy. This nanoconstruct induced major changes in the nuclear phenotype in cancer cells through nuclear envelope (NE) invaginations. Biological responses of the cells after the release of aptamer indicated elevations in both apoptosis signals and cancer cell death. Cancer cells with more NE folding showed increased apoptosis as well as decreased cell viability. Significantly, femtosecond, light-triggered release of aptamers from AuNSs near the nucleus produced approximately the same apoptosis and viability results as concentrations of free aptamer (10 μM) used in vitro, clinical dosages. Therefore, AuNSs are excellent platforms for delivering localized concentrations of aptamer or other small-molecule drugs that can maximize anticancer efficacy.
- *Inventors
- Teri Odom*Jung Heon LeeDuncan Hieu M. Dam
- 國家/地區
- 美國
