Amazonian Plants with Selective Anticancer Properties (12010)
- *Abstract
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Features and Benefits
- Potential compounds for prostate cancer studies and development as cancer therapies.
- Developed from natural product extracts.
- Potent and selective activity against hormone-refractory prostate cancer in pre-clinical assays.
*This Technology is available for licensing, further development, or industrial partnering*
Technology
Prostate cancer is one of the most common cancers affecting men. Researchers at the University of Louisville have isolated and identified three new compounds, Physangulidine A, B and C, from the plant species, Physalis angulate, that have initial anti-cancer activity in pre-clinical assays. The UofL researchers have shown that Physangulidine A (SPA-14-3-4) promotes cell death through the induction of apoptosis in prostate cancer cell lines. Because these compounds were identified and isolated from natural plant products, it is hoped that these compounds will have low cytotoxicity which serves advantageous for cancer patients undergoing treatment.
Markets Addressed
In the United States, prostate cancer is the second leading cause of cancer death in men; yet, with early diagnosis, it is treatable. Currently, options for treatment of prostate cancer include surgery and radiation therapy; however, surgery is invasive with certain risks, and radiation therapy requires the patient to be exposed to high levels of cytotoxicity. Also, there is very little data showing the effectiveness and/or possible side effects that can come with these current treatments. There is great demand for development of a chemotherapeutic agent with low cytotoxic effects.
Technology Status
- IP Status: Patent Pending.
- Development Status: Pre-clinical research in prostate cancer cell lines.
- Fields of Use Available: All Commercial Fields.
- Publications: Reyes-Reyes, E. M. et al., Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells, Journal of Natural Products, Vol. 76, No. 1, January 2013.; andJin, Z. et al., Physangulidines A, B, and C: three new antiproliferative withanolides from Physalis angulata L, Organic Letters, Vol. 14, No. 5, March 2012.
- 國家/地區
- 美國
