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Thermal Contrast Reader for Lateral Flow Assay

詳細技術說明

Improved Lateral Flow Assay ReaderWith the importance of screening for diseases increasing, this technology introduces a thermal assay technique designed to outperform current methods in the detection of nanoparticles and other exogenous or endogenous particles within biological systems such as media, cells and tissues. This thermal assay technique has demonstrated a more than 32-fold improvement in sensitivity in detecting analytes in lateral flow assay strips when compared to visual inspection methods. With those results, the necessity of more complicated lab procedures like latex agglutination and enzyme-linked immunosorbent assay methods may be reduced. The thermal contrast reader for lateral flow assays (LFA) cuts down on time and costs, increasing the value of this thermal assay technique.More Efficient than ELISACurrent techniques to characterize the uptake of nanoparticles and exogenous additives in biological systems are expensive, labor intensive, and time consuming. The new thermal assay technique could replace common assays such as ELISA, AES, or ISP-MS with reduced cost and increased speed. Nanoparticles and other exogenous agents are being increasingly used in diagnostic and therapeutic purposes. This technique takes advantage of the heat generation of those nanoparticles along with other exogenous particles and additives that generate thermal contrast. This allows for fast and inexpensive quantification of the amount and location within biological systems.FEATURES AND BENEFITS OF LATERAL FLOW ASSAY READER TECHNIQUE:- Potential for gains in detection limit of upward of 10,000 times- Applicable to a wide range of LFA substrates, nanoparticle compositions and geometries- Non-destructive test- Reduces cost and labor- Sensitivity similar to ELISA assays- Handheld reader for point of care testing

*Abstract

None

*Principal Investigation

Name: John Bischof, Professor

Department: Department of Mechanical Engineering

國家/地區

美國