Detect Free Radicals and Monitor Chronic Inflammation Without Adverse Side Effects
Widely effective Non-toxic Not subject to extensive drug testing and approval process
AlzheimerΓÇÖs disease Cancer chemotherapy Transplants or prosthetic devices CrohnΓÇÖs disease Inflammatory bowel disease Arthritis Multiple sclerosis Ulcerative colitis
This new device, a nano-sized encapsulated unit comprised of two separate compartments, each externally permeable, contains nanoceria in one and a flourophore imaging agent in the other. Nanoceria, when in the presence of excess ROS, affects the flourophore by altering its level of fluorescence emission (increase or decrease in the signal measured via optical methods), altering its magnetic relaxation (increase or decrease in the signal assessed via MRI), or altering other properties such as X-ray contrast. The combined detection and imaging components provide a method for monitoring ROS levels indicating inflammation.
美國
