Polyplex Gene Delivery Vectors
- 技術優勢
- - First development of these cyclic polymers- Increases strength of synergistic binding to oligonucleotides- Provides potential to improve gene therapy technologies
- 技術應用
- These smaller cyclic polymers are biocompatible and water-soluble. They act as intermediates for preparing cyclic poly (ethylene imine) (PEI). These polymers are a critical factor in both the complexation of DNA and its transfection into cells. These polymers are of great use in the study of siRNA delivery.
- 詳細技術說明
- This technology potentially can be used for both in vitro and in vivo gene therapy. Production of these cyclic polymers with low molecular weights has been completed on the small scale. Data has resulted with full characterization of linear precursors and cyclic products. With optimization methods, this technology has the potential to be produced with increased molecular weights and to be scaled up in volume.
- *Abstract
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Preparation of cyclic poly(N-acylethylene imine) and cyclic poly(ethylene imine)
- *Principal Investigation
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Name: Scott Grayson
Department:
- 國家/地區
- 美國
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