Multifunctional Drug Formulations And Compositions Thereof
The multifunctional property of sandalwood oil/santalol and flaxseed oil offers a number of unique advantages for the delivery of drugs for prevention and treatment of cancer and other diseases.
We have developed a formulation that can harness the multifunctional properties of multiple therapeutic agents. Several oil in water emulsion formulations (nano and micro emulsions) were developed using alpha santalol or flaxseed oil as the oil phase. Alpha santalol is known to have anti-cancer properties (skin, breast and prostate cancers, among others). It also has skin penetration enhancing properties. Alpha santalol or sandalwood oil can be used as the oil phase of the emulsion. Flaxseed oil is a rich source of PUFA and is known to have beneficial effects in prevention and treatment of cancer, cardiovascular, diabetes and inflammatory disorders. The components of PUFA (i.e., linolenic acid and linoeleic acid) are known to have skin penetration enhancing properties. Further, the flaxseed oil can be used as the oil phase in the emulsion. In a furthermodification of the formulation, both alpha santalol (or sandalwood oil) and PUFA were used as the oil phase in the emulsion. This formulation in addition to synergistically increasing the skin penetration may also lead to enhanced anti-cancer or antiinflammatory activity. Further, it can be used to deliver other therapeutic agents.
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