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MUTEINS OF HYPOXIA INDUCIBLE FACTOR ALPHA AND METHODS OF USE THEREOF

技術優勢

Tissue hypoxia, Angiogenesis

技術應用

Since HIF-1 is a transcription factor that controls the expression of multiple genes involved in angiogenesis, it will provide a superior clinical outcome compared to treatment with a single angiogenic factor (such as vascular endothelial growth factor, for example). Further, since the HIF mutein resists degradation in nonhypoxic tissue, one may prophylactically treat tissue that may become hypoxic at a later time. For example, a narrowed coronary vessel may become completely occluded either by spasm or a clot, resulting in a myocardial infarction (heart attack). One may use the stable HIF mutein to induce angiogenesis in these patients, even if there is no hypoxia at the time, in order to prevent heart attacks.

詳細技術說明

Hypoxia occurs when the demand for oxygen in a tissue exceeds the supply. Hypoxia inducible factor-1 (HIF-1) is a mammalian transcription factor that is expressed in response to hypoxia; further, hypoxia acts to increase the steady-state levels of HIF-1since the protein is prone to degradation in the presence of oxygen. This technology provides a HIF mutein that is more resistant to degradation (as compared to the wild-type protein) under nonhypoxic conditions. This translates into an increased half-life for the mutein in nonhypoxic conditions, and opens several new possibilities for therapeutic and prophylactic treatment of hypoxia and ischemia related tissue damage, as well as for modulating angiogenesis or vascularization.

*Abstract

This technology provides a HIF mutein that is more resistant to degradation (as compared to the wild-type protein) under nonhypoxic conditions.

附加資料

Inventor: CHEN, Zhuo-ming | SU, Guo-hui | CHEN, Pei
Priority Number: CN101868298B
IPC Current: B01J001314 | A61K000950 | A61K000952
Assignee Applicant: The University of Hong Kong
Title: Collagen-based microspheres and methods of preparation and use thereof
Usefulness: Collagen-based microspheres and methods of preparation and use thereof
Summary: The method is for preparing natural extracellular matrix-based microspheres or population of microspheres for forming into structures for use in tissue engineering (claimed), and useful for drug delivery as well as cell culture i.e. three dimensional cell culture and implantation. The microspheres or microparticles can be formed into additional structures as coatings, encapsulated, or incorporated into other materials that act as binders, e.g. for use as tissue engineering matrices.
Novelty: Preparation of natural extracellular matrix-based microspheres by initiating sol-gel transition of natural extracellular matrix components, decelerating sol-gel transition, forming water-in-oil emulsion, and accelerating sol-gel transition

主要類別

生物醫學

細分類別

醫藥成分

國家/地區

美國