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PREDICTING THE RISK OF PROSTATE CANCER MORBIDITY AND MORTALITY

技術應用: Using a blood test as the source of genomic DNA, a method of using a PCR assay to determine the CAG trinucleotide repeat length in microsatellite DNA of exon 1 of the androgen receptor. The number of such repeats correlates with the aggressiveness and prognosis of prostate cancer.

詳細技術說明: It has been found, that CAG repeat length is inversely associated with cancers characterized as ΓÇ£aggressive.ΓÇØ Risk of advanced, aggressive, or fatal disease is particularly strongly related to CAG length among older men.The results herein also provide evidence that the variability in the androgen receptor CAG microsatellite influences the risk of developing ΓÇ£aggressiveΓÇØ prostate cancer. As a result, a method of predicting the onset of aggressive prostate cancer and the risk of mortality from the prostate cancer is available. The present invention additionally relates to the discovery that the length of the TA repeat polymorphism in the 5-alpha reductase gene is directly related with risk of aggressive disease.

*Abstract: The invention is based on discovery that the number of CAG repeats in the androgen receptor determines the aggressiveness of prostate cancer and the likelihood that a patient of at least about 60 years of age will die of the disease.

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