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Monoclonal anti-kindlin-1 (also known as KIND1, KINDLERIN, UNC112-RELATED PROTEIN 1 (URP1) ) antibody

*Abstract: Kindlin-1 (also known as KIND1, KINDLERIN, UNC112-RELATED PROTEIN 1 (URP1) ) is an important component of cell-extracellular matrix adhesion. Kindlin-1 is involved in cell adhesion, possibly via its interaction with integrins and may mediate TGF-beta 1 signaling during tumor progression. Kindlin-1 has been shown to be significantly upregulated in lung and colon carcinomas. Mutations in the kindlin-1 gene, FERMT1, causes Kindler syndrome. Kindler syndrome is an autosomal recessive disorder characterized by neonatal blistering, sun sensitivity, atrophy, abnormal pigmentation and fragility of the skin. We have developed monoclonal anti-kidlin-1 antibodies. This monoclonal antibody recognizes kindlin-1 in multiple assays including Western blotting, immunoprecipitation, immunohistochemical and immunofluorescent staining. Antigen: Kindlin-1Clone Name: 4A5.14Isotype: Immunogen: human kindlin residues 216-677Applications: WB, IHC, IPSpecies reactivity: human Gene/Protein information: Entrez Gene: 55612; UniProtKB: Q9BQL6For more information please see manuscript: Histopathology (2007) 51(4):499-508.

*Principal Investigation: Name: Chuanyue Wu, Associate Professor
Department: Med-Pathology

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